Assisted particle size reduction process

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United States of America Patent

PATENT NO 10328027
APP PUB NO 20160346206A1
SERIAL NO

15115193

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Abstract

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A new scalable process to control the particle size and the particle size distribution, comprising 5 steps: (i) suspension preparation in a mixture of solvents in which the API and/or excipient is partially soluble in one of the solvents; (ii) particle size reduction of the suspension; (iii) aging; (iv) stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.

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Patent Owner(s)

Patent OwnerAddress
HOVIONE INTERNATIONAL LTDHONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cacela, Constanca Lisbon, PT 4 13
Costa, Eunice Santa Iris da Azoia, PT 4 1
Sobral, Luis Loures, PT 13 10
Temtem, Marcio Quinta do Conde, PT 8 26
Villax, Peter Lisbon, PT 11 422

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