METHOD AND SYSTEM FOR SEQUENCING IN CHARACTERIZATION OF ANTIBODY BINDING BEHAVIOR

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United States of America Patent

APP PUB NO 20160362742A1
SERIAL NO

15183652

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Abstract

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A method and system for characterization of antibody-bound targets by sequencing of synthetic oligonucleotides bound to the antibodies, the method including: receiving a sample having a set of antibodies; conjugating each of the set of antibodies with an oligonucleotide, thereby generating a set of oligonucleotide-conjugated antibodies; binding a first subset of the set of oligonucleotide-conjugated antibodies to a set of targets at a capture substrate; determining a sequence for at least one of: 1) each oligonucleotide of the first subset of oligonucleotide-conjugated antibodies that bind to the set of targets and 2) each oligonucleotide of a second subset of the set of oligonucleotide-conjugated antibodies that fail to bind to the set of targets; and generating an analysis of the sample from the sequences determined from at least one of the first and the second subsets of oligonucleotide-conjugated antibodies.

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Patent Owner(s)

Patent OwnerAddress
PSOMAGEN INC1330 PICCARD DR ROCKVILLE MD 20850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Almonacid, Daniel San Francisco, US 108 785
Apte, Zachary San Francisco, US 112 945
Richman, Jessica San Francisco, US 112 945

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