Therapeutic Agent for Ocular Disease or Prophylactic Agent for Ocular Disease
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United States of America Patent
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Issued Date -
Dec 22, 2016
app pub date -
Oct 17, 2014
filing date -
Oct 21, 2013
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Abstract
Because 3-[(3S, 4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile suppresses an increase of the retinal vascular permeability induced by VEGF, it can be used as an active ingredient of a therapeutic or preventive agent for various eye diseases involving VEGF, such as age-related macular degeneration, diabetic retinopathy, macular edema, neovascular maculopathy, retinal vein occlusion and neovascular glaucoma.
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