Nanoparticle Composition for Use in Targeting Cancer Stem Cells and Method for Treatment of Cancer
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United States of America Patent
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Issued Date -
Dec 22, 2016
app pub date -
Jun 22, 2015
filing date -
Jun 22, 2015
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Abstract
There is provided a nanoparticle composition comprising a central core portion including magnetic nanoparticles adapted to act as a heat source and a chemotherapeutic agent configured to treat cancer tissues in issue, a shell portion including a shell member encapsulating the core portion, antibodies configured to target cancer stem cells in issue and adhered to surface of said shell member. There is also provided a method comprising a step of exposing a target site in which the cancer cells reside to an energy source for effecting elevation of temperature of the magnetic nanoparticles, and release of the chemotherapeutic agent from the shell portion for destroying the cancer cells of the composition-cancer cell complex in the target site, wherein the energy source is an alternating magnetic field whereby extent of elevation of temperature and release of the chemotherapeutic agent is controllable by the alternating magnetic field.
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