CYTOTOXIC BENZODIAZEPINE DERIVATIVES
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United States of America Patent
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app pub date -
Jun 1, 2016
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Sep 3, 2014
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Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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