PURIFICATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR SACCHARIDES

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United States of America Patent

APP PUB NO 20160376301A1
SERIAL NO

15258881

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Abstract

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The invention provides a method for releasing capsular polysaccharide from S. aureus type 5 or type 8 cells, comprising the step of treating the cells with acid. The invention further provides a process for purifying capsular polysaccharide from S. aureus type 5 or type 8 cells comprising this method. Other processing steps may be included in the process, such as enzymatic treatment, e.g. to remove nucleic acid, protein and/or peptidoglycan contaminants; diafiltration, e.g. to remove low molecular weight contaminants; anion exchange chromatography, e.g. to remove residual protein; and concentration.

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE BIOLOGICALS SARIXENSART

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BERTI, Francesco Colle Val D'Elsa, IT 50 157
COSTANTINO, Paolo Colle Val D'Elsa, IT 53 308
ROMANO, Maria Rosaria Pontedera, IT 20 47

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