METHOD FOR PRODUCING A FUSION MIXTURE FOR TRANSFER OF A CHARGED MOLECULE INTO AND/OR THROUGH A LIPID MEMBRANE

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United States of America Patent

APP PUB NO 20170009255A1
SERIAL NO

15205967

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Abstract

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A method for producing a fusion mixture for a transfer of a charged molecule into and/or through a lipid membrane is disclosed. In an embodiment, the method comprises: providing an initial mixture comprising a positively charged amphipathic molecule A, an aromatic molecule B with hydrophobic range and a neutral, amphipathic molecule C, whereby the molecule types are at hand in a ratio A:B:C of 1-2:0.02-1:0-1 mol/mol; generating a fusogenic liposome by absorption of the initial mixture in a watery solvent; providing a charged molecule; forming a complex from the charged molecule and a neutralizing agent; and incubating the complex with the fusogenic liposome so that a fusion mixture is obtained.

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Patent Owner(s)

Patent OwnerAddress
BENIAG GMBH52428 JÜLICH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Csiszar, Agnes Julich, DE 4 4
Hersch, Nils Wegberg, DE 4 5
Hoffmann, Bernd Julich, DE 26 62
Hoffmann, Marco Wegberg, DE 10 147
Merkel, Rudolf Julich, DE 11 52
ZANTL, Roman Baldham, DE 21 64

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