Method for purifying darbepoetin alfa
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United States of America Patent
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Jul 28, 2020
Grant Date -
Jan 26, 2017
app pub date -
Nov 28, 2014
filing date -
Nov 29, 2013
priority date (Note) -
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Abstract
The present invention relates to a method for purifying darbepoetin alfa by selectively separating only a structural isoform having a high content of sialic acid from a mixture of structural isoforms of darbepoetin alfa having various contents of sialic acid. Since the method of the present invention is a novel method for purifying darbepoetin alfa which can be conveniently and simply produced, it is possible to remarkably increase productivity due to process efficiency improvement, as well as to yield high purity darbepoetin alfa when mass-producing darbepoetin alfa according to the present invention.
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