10′,11′-modified saxitoxins useful for the treatment of pain

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10106549
APP PUB NO 20170029431A1
SERIAL NO

15302964

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10′,11′-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10′,11′-modified saxitoxins are of Formula I: where R1, R2 and R3 are as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10′,11′ modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human.

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Patent Owner(s)

  • SITEONE THERAPEUTICS, INC.; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Axtman, Matthew Cary, US 2 5
Du, Bois Justin Menlo Park, US 10 52
Merit, Jeffrey E San Diego, US 20 88
Miljanich, George Redwood City, US 8 28
Mulcahy, John Redwood City, US 15 121
Pajouhesh, Hassan Redwood City, US 46 382
Walker, James Menlo Park, US 61 789

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