NOVEL PURIFICATION PROCESS OF GONADOTROPIN
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United States of America Patent
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Feb 2, 2017
app pub date -
Apr 17, 2015
filing date -
Apr 18, 2014
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Abstract
The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating protein. The process of purification of the desired gonadotropin according to the present invention comprises use of an affinity chromatography as the first column purification step, prior to use of any column chromatography steps for further purification. Such purification process may further include ion exchange and/or hydrophobic interaction chromatography step to obtain substantially purified gonadotropin protein with desired isoforms profile.
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