Methods and compositions for treating metastatic breast cancer and other cancers in the brain

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United States of America Patent

PATENT NO 10780182
APP PUB NO 20170043035A1
SERIAL NO

15306413

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hinderer, Christian Philadelphia, US 39 37
Rothwell, William Thomas Philadelphia, US 4 20
Wilson, James M Glen Mills, US 387 10657

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