Methods and Compositions to Modulate RNA Processing
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United States of America Patent
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Feb 16, 2017
app pub date -
May 26, 2016
filing date -
Dec 18, 2012
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Abstract
The present disclosure provides methods and compositions to selectively modulate RNA processing. The methods and compositions selectively enhance or repress RNA processing by up- or down-regulating Drosha expression and/or by providing RNA sequences with mismatches introduced or removed 5 and/or 9-12 nucleotide positions from the Drosha cutting site. Therapeutic uses of the methods and compositions are also described.
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