FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET
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United States of America Patent
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Feb 23, 2017
app pub date -
Aug 15, 2016
filing date -
Feb 27, 2013
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Abstract
The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
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