SDF-1 DELIVERY FOR TREATING ADVANCED ISCHEMIC CARDIOMYOPATHY
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United States of America Patent
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Feb 23, 2017
app pub date -
Apr 28, 2015
filing date -
Apr 28, 2014
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Abstract
Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Methods of treating subjects with advanced ischemic cardiomyopathy are further disclosed herein.
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