Safe sequencing system

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United States of America Patent

PATENT NO 11180803
APP PUB NO 20170051347A1
SERIAL NO

15240034

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Abstract

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Though massively parallel sequencing instruments are in principle well-suited to the task of identification of mutations present in a small fraction of DNA templates, the error rates in such instruments are generally too high to allow confident identification of rare variants. An approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose is called “Safe-SeqS” for (Safe-Sequencing System) and includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ≥95% of them contain the identical mutation.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinde, Isaac Beaumont, US 6 638
Kinzler, Kenneth W Baltimore, US 281 4765
Papadopoulos, Nickolas Towson, US 89 1067
Vogelstein, Bert Baltimore, US 323 6289

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