Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
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United States of America Patent
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Dec 1, 2020
Grant Date -
Mar 2, 2017
app pub date -
May 8, 2015
filing date -
May 8, 2014
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Abstract
A method of making optically pure preparations of chiral γPNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral γPNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed γPNA, and vice-versa, are provided.
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