Clomiphene synthesis using a single solvent

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United States of America Patent

PATENT NO 9914696
APP PUB NO 20170073302A1
SERIAL NO

15123577

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Abstract

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The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.

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Patent Owner(s)

Patent OwnerAddress
REPROS THERAPEUTICS INCTHE WOODLANDS TX 77380

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hsu, Kuang The Woodlands, US 12 30
Podolski, Joseph S The Woodlands, US 60 311

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