MONOCLONAL ANTIBODIES TO INTERLEUKIN 35 AND METHODS OF USE THEREOF TO INHIBIT REGULATORY T CELL FUNCTION
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United States of America Patent
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Issued Date -
Mar 16, 2017
app pub date -
Nov 4, 2016
filing date -
Sep 22, 2006
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Abstract
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
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