GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE
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United States of America Patent
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Mar 23, 2017
app pub date -
Sep 20, 2016
filing date -
Sep 21, 2015
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Abstract
Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa) residues of the protein all ranges and values within the explicitly stated range are contemplated: e.g., from 148 to 69. Animals expressing SLICK have superior thermoregulatory ability compared to non-slick animals and experience a less drastic depression in milk yield during the summer.
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