METHODS AND COMPOSITIONS FOR INCREASING A T-EFFECTOR CELL TO REGULATORY T CELL RATIO

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United States of America Patent

APP PUB NO 20170080064A1
SERIAL NO

15123468

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Abstract

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The present invention is directed to methods for increasing T-cell effector cell to regulatory T cell ratio. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and tumor-associated antigen.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL INSTITUTE OF HEALTH (NIH) U S DEPT OF HEALTH AND HUMAN SERVICES (DHHS) U S GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR) OFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH6011 EXECUTIVE BOULEVARD SUITE 325 MSC 7660 BETHESDA MD 20892-7660

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berzofsky, Jay A Bethesda, US 62 364
Chen, Zhisong Potomac, US 2 27
Khleif, Samir Silver Spring, US 24 164
Petit, Robert Newtown (Wrightstown), US 71 847
Wallecha, Anu Yardley, US 25 385

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