NITRITE AND NITRITE-METHEME THERAPY TO DETOXIFY STROMA-FREE HEMOGLOBIN BASED BLOOD SUBSTITUTES

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United States of America Patent

SERIAL NO

15146190

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Abstract

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This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE U S A AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SROCKVILLE MD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gladwin, Mark T Pittsburgh, US 21 174
Kerby, Jeffrey Birmingham, US 3 5
Kim-Shapiro, Daniel B Winston-Salem, US 12 103
Patel, Rakesh P Hoover, US 8 95

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