COMPOSITIONS AND METHODS THAT TARGET OLFACTORY RECEPTORS FOR REGULATION OF BREATHING

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United States of America Patent

APP PUB NO 20170100353A1
SERIAL NO

15290380

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Abstract

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The olfactory receptor Olfr78/OR51E2 is shown to be expressed in the carotid body and to control breathing responses regulated by acute hypoxia sensing. Activation of Olfr78/OR51E2 increases breathing, while inhibitors of the receptor can counteract this activity. A native agonist of Olfr78/OR51E2 is shown to be lactate.

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Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYOFFICE OF THE GENERAL COUNSEL BLDG 170 3RD FL MAIN QUAD PO BOX 20386 STANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Andy Ju-An Menlo Park, US 1 0
Krasnow, Mark Alan Stanford, US 2 0

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