Gemcitabine prodrugs

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United States of America Patent

PATENT NO 10662213
APP PUB NO 20170107246A1
SERIAL NO

15308491

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Abstract

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This invention relates to a prodrug of the monophosphate nucleotide of the well-known oncology drug gemcitabine. Specifically, it relates to gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate when present as a single phosphate diastereoisomer and, in particular, it relates to the (S)-phosphate diastereoisomer which offers a remarkable and unexpected increase in solubility relative to the (R)-diastereoisomer. The (S)-phosphate epimer is also preferentially taken up into cyclodextrin solutions over the (R)-diastereoisomer.

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Patent Owner(s)

Patent OwnerAddress
NUCANA BIOMED LIMITED78 CANNON STREET LONDON EC4N 6AF

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ferrari, Valentina Cardiff South Glamorgan, GB 5 24
Griffith, Hugh Edinburgh, GB 37 176
McGuigan, Christopher Cardiff South Glamorgan, GB 46 1233
Serpi, Michaela Cardiff South Glamorgan, GB 11 35
Slusarczyk, Magdalena Cardiff South Glamorgan, GB 14 100

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