TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY

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United States of America Patent

SERIAL NO

15299603

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Abstract

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Compounds are disclosed that inhibit the methylerythritol cytidyltransferase (IspD) enzyme in the non-mevalonate pathway (MEP pathway), which is present in many organisms including the P. falciparum parasite. Inhibitors of the IspD enzyme in the non-mevalonate pathway of the P. falciparum parasite are useful for treating malaria.

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Patent Owner(s)

  • THE UNIVERSITY OF LIVERPOOL;WASHINGTON UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berry, Neil Liverpool, GB 8 10
O'Neill, Paul Liverpool, GB 15 137
Odom, Audrey St. Louis, US 3 1

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