PROCESSES FOR PREPARING BREXPIPRAZOLE
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United States of America Patent
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Issued Date -
May 25, 2017
app pub date -
Nov 1, 2016
filing date -
Nov 3, 2015
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Abstract
The present disclosure provides processes for preparing brexpiprazole. The present disclosure also provides processes for the purification of brexpiprazole. The processes for preparing and purifying brexpiprazole of the present invention provide substantial improvements over currently known methods. In certain embodiments, the conversion of Formula XI and XII to form XIII provides increased selectivity over previously reported methods. This offers increased yield and purity. The improved process for purifying brexpiprazole disclosed herein provides brexpiprazole with superior purity and is also more suitable for industrial production.
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