PEPTIDE INHIBITORS OF CASPASE 2 ACTIVATION
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United States of America Patent
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May 25, 2017
app pub date -
Jun 27, 2016
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Sep 9, 2011
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Abstract
The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino acid sequence AFDAFC as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, amyotrophic lateral sclerosis, Huntington's chorea, and Creutzfeld-Jacob disease.
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