HBV polymerase mutants
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United States of America Patent
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Jan 29, 2019
Grant Date -
May 25, 2017
app pub date -
Dec 5, 2016
filing date -
Jul 12, 2011
priority date (Note) -
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Abstract
The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.
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