Functionalized polymer hybrids
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United States of America Patent
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Sep 19, 2017
Grant Date -
Mar 17, 2016
app pub date -
Apr 17, 2014
filing date -
Apr 18, 2013
priority date (Note) -
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Abstract
A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
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