ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF

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United States of America Patent

APP PUB NO 20170166633A1
SERIAL NO

15389627

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

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Patent Owner(s)

Patent OwnerAddress
ABBVIE DEUTSCHLAND GMBH & CO KGMAX-PLANCK-RING 2A WIESBADEN 65205

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bardwell, Philip Boston, US 13 135
Barlow, Eve Wellesley, US 5 30
Hsieh, Chung-Ming Newton, US 102 909
Leddy, Mary North Attleborough, US 8 49
Mueller, Bernhard K Neustadt, DE 19 108
Schmidt, Martin Bensheim, DE 178 1547

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