ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF
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United States of America Patent
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Issued Date -
Jun 15, 2017
app pub date -
Dec 23, 2016
filing date -
Feb 29, 2008
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Abandoned
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Abstract
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
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