TARGETED DISRUPTION OF THE MHC CELL RECEPTOR
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United States of America Patent
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Jun 22, 2017
app pub date -
Dec 15, 2016
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Dec 18, 2015
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Abstract
Disclosed herein are methods and compositions for inactivating MHC genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
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