Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyrdin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide

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United States of America Patent

PATENT NO 10150753
APP PUB NO 20170174661A1
SERIAL NO

15387560

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Abstract

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Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

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  • 501 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burke, Jason P Houston, US 18 150
Jones, Philip Houston, US 179 1283
Le, Kang Sugar Land, US 29 205
Liu, Gang Sugar Land, US 576 5577
Soth, Michael J Sugar Land, US 26 163

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