Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof

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United States of America Patent

PATENT NO 10023579
APP PUB NO 20170174694A1
SERIAL NO

15382213

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Abstract

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The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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Patent Owner(s)

Patent OwnerAddress
SOUTHERN RESEARCH INSTITUTECOMMERCIALIZATION AND INTELLECTUAL PROPERTY 2000 9TH AVENUE SOUTH P O BOX 55305 BIRMINGHAM AL 35205-5305

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ananthan, Subramaniam Birmingham, US 33 218
Augelli-Szafran, Corinne E Homewood, US 33 27
Galemmo, Robert San Francisco, US 2 2
Gupta, Vandana Birmingham, US 11 70
Moukha-Chafiq, Omar Birmingham, US 12 5
Suto, Mark Birmingham, US 5 6

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