Long-acting recombinant human follicle-stimulating hormone-Fc fusion protein

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United States of America Patent

PATENT NO 10023624
APP PUB NO 20170174736A1
SERIAL NO

15033286

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Recombinant Fc fusion proteins of human follicle-stimulating hormone (hFSH) with in vivo biological activities comparable to those of human follicle-stimulating hormone are disclosed. A recombinant hFSH-Fc fusion protein comprises β subunit of hFSH (hFSH β), CTP, α subunit of hFSH (hFSH α), a flexible peptide linker, and human IgG2 Fc variant (vIgG2Fc). A method is also disclosed to make such fusion proteins at good expression levels. These recombinant hFSH-Fc fusion proteins of the present disclosure exhibit sufficient biological activities and prolonged plasma half-lives, leading to improved pharmacokinetics and pharmacodynamics. Thus, a lower dosage may be used and/or better or different therapeutic efficacies with less side effects may be achieved. A method for the application of the recombinant hFSH-Fc fusion proteins in the treatment and/or prevention of human infertility is also disclosed.

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Patent Owner(s)

  • UNICOHEALTH CO. LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hou, Yongmin Guangzhou, CN 3 10
Li, Qiang Guangzhou, CN 802 10809
Liao, Sha Guangzhou, CN 11 5
Wu, Maobo Guangzhou, CN 1 4
Xu, Zhenqi Guangzhou, CN 1 4
Zhang, Yujie Guangzhou, CN 50 318

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