Methods for modulating Ataxin 2 expression

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United States of America Patent

PATENT NO 10006027
SERIAL NO

15127352

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Abstract

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Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism. Provided are methods for reducing expression of Ataxin 2 (ATXN2) mRNA and protein in an animal. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases, including spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism by inhibiting expression of Ataxin 2 in an animal.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.; UNIVERSITY OF UTAH RESEACH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bennett, C Frank Carlsbad, US 408 7358
Freier, Susan M San Diego, US 510 6154
Hung, Gene San Diego, US 43 474
Pulst, Stefan M Salt Lake City, US 21 86
Scoles, Daniel R Salt Lake City, US 7 50

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