MARKERS AND THERAPEUTIC INDICATORS FOR GLIOBLASTOMA MULTIFORME (GBM)

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United States of America Patent

SERIAL NO

15390276

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A signature of proteins occurring in glioblastoma multiforme (GBM) tissue comprised of 33 cell surface proteins (GBMSig) that distinguish subjects with GBM from healthy controls with more than 98% accuracy is described. In addition, four of the members of this signature are particularly useful as blood-borne markers of GBM. Certain other members of the signature are indicators of the possible efficacy of the use of TGF-β1 inhibitors in the treatment of this condition. Methods to treat and to stratify GBM based on GBMSig proteins are also disclosed.

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Patent OwnerAddress
INSTITUTE FOR SYSTEMS BIOLOGYSEATTLE WA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
COBBS, Charles S Mercer Island, US 3 92
GHOSH, Dhimankrishna Seattle, US 3 18
HOOD, Leroy Seattle, US 40 2617
PRICE, Nathan D Seattle, US 2 0

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