ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS

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United States of America Patent

SERIAL NO

15457153

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Abstract

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An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. In a preferred embodiment, a drug is modified to increase its lipophilicity. In some embodiments the modified drug is homogeneously dispersed within spherical microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and/or organic solvent insoluble. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.

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Patent Owner(s)

Patent OwnerAddress
COLLEGIUM PHARMACEUTICAL INC400 HIGHLAND CORPORATE DRIVE CUMBERLAND RI 02864

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fleming, Alison B North Attleboro, US 21 849
Hirsh, Jane Wellesley, US 36 1613
Klibanov, Alexander M Boston, US 57 1963
RARIY, Roman V Allston, US 40 1363

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