Use of noggin, an ALK5 inhibitor and a protein kinase c activator to produce endocrine cells

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United States of America Patent

PATENT NO 10704025
APP PUB NO 20170183630A1
SERIAL NO

15457956

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Abstract

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The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

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Patent Owner(s)

  • JANSSEN BIOTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Xu, Jean Raritan, US 62 1095

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