Methods for inhibiting fibrosis in a subject in need thereof
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United States of America Patent
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Aug 11, 2020
Grant Date -
Jul 6, 2017
app pub date -
Jan 5, 2017
filing date -
Jan 5, 2016
priority date (Note) -
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Abstract
In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
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