Conditionally active biological proteins

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United States of America Patent

PATENT NO 10329556
APP PUB NO 20170191055A1
SERIAL NO

15308659

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Abstract

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This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at some physiological conditions. For example, conditionally active biologic proteins are active in tumors, but virtually inactive at other body parts, or conditionally active antibodies cap able of crossing blood-brain-barrier.

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Patent Owner(s)

Patent OwnerAddress
BIOATLA INC11085 TORREYANA ROAD SUITE 100 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Hwai Wen San Marcos, US 89 1213
Frey, Gerhard San Diego, US 107 962
Short, Jay M Del Mar, US 274 5063

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