PSGL-1 modulators and uses thereof

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United States of America Patent

PATENT NO 10858436
APP PUB NO 20170198047A1
SERIAL NO

15324262

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Abstract

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The present invention relates to the seminal discovery that P-selectin glycoprotein ligand-1 (PSGL-1) modulates the immune system and immune responses. Specifically, the present invention provides PSGL-1 agonists and antagonists which increase the survival of multifunctional T cells and viral clearance. The present invention further provides methods of treating infectious diseases, cancer and immune and inflammatory diseases and disorders using a PSGL-1 modulator.

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Patent Owner(s)

  • SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bradley, Linda M La Jolla, US 4 0
Tinoco, Roberto La Jolla, US 5 0

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