Delivery of therapeutic agents by a collagen binding protein
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United States of America Patent
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May 11, 2021
Grant Date -
Jul 20, 2017
app pub date -
Jan 17, 2017
filing date -
Dec 14, 2011
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Abstract
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
First Claim
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS; MONTEFIORE MEDICAL CENTER; THE KITASATO INSTITUTE; NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Gensure, Robert C | New York, US | 12 | 113 |
Katikaneni, Ranjitha | New York, US | 5 | 34 |
Koide, Takaki | Tokyo, JP | 8 | 36 |
Matsushita, Osamu | Kanagawa, JP | 26 | 230 |
Nishi, Nozomu | Kagawa, JP | 16 | 101 |
Philominathan, Sagaya Theresa Leena | Cheshire, US | 5 | 34 |
Ponnapakkam, Tulasi | New York, US | 10 | 74 |
Sakon, Joshua | Fayetteville, US | 18 | 108 |
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