Method of computational protein design

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United States of America Patent

PATENT NO 10665324
APP PUB NO 20170206308A1
SERIAL NO

15323994

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Abstract

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A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.

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Patent Owner(s)

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YEDA RESEARCH AND DEVELOPMENT CO LTD7610002 REHOVOT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fleishman, Sarel Rehovot, IL 14 9
Lapidoth, Gideon Rehovot, IL 1 3
Norn, Christoffer Rehovot, IL 2 3
Pszolla, Maria Gabriele Rehovot, IL 1 3

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