A Method of Preparing Amorphous Solid Dispersion in Submicron Range by Co-Precipitation
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United States of America Patent
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Jul 27, 2017
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Jul 31, 2015
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Aug 1, 2014
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Abstract
The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-precipitation, using microfluidization/microreaction technology to promote high energy mixing/interaction at a micro and/or molecular level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro- and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.
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