CONSTRUCTION METHOD FOR HEURISTIC METABOLIC CO-EXPRESSION NETWORK AND THE SYSTEM THEREOF
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United States of America Patent
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Jul 27, 2017
app pub date -
Jun 30, 2016
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Jan 25, 2016
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Abstract
The present invention discloses a construction method for heuristic metabolic co-expression network and the system thereof. Based on the max-dependent criteria, the present invention treats the characterized multivariate mutual information of a plurality of metabolites as mutual function value, and applies an optimization searching for the best feature subset, with a heuristics computational intelligence multimodal optimization algorithm. And by running the optimization process in a plurality of times, combining and studying the results in each time running, a co-expression network structure is built. Finally, a threshold for segmentations is calculated through probability models, and an exact and stable metabolic co-expression network is obtained.
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