Bispecific T cell engaging antibody constructs

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United States of America Patent

PATENT NO 11434302
APP PUB NO 20170218078A1
SERIAL NO

15422647

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Abstract

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The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

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Patent Owner(s)

Patent OwnerAddress
AMGEN RESEARCH (MUNICH) GMBH81477 MÜNCHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bogner, Pamela Munich, DE 10 73
Brozy, Johannes Munich, DE 15 105
Friedrich, Matthias Munich, DE 18 162
Hoffmann, Patrick Munich, DE 69 1097
Kufer, Peter Munich, DE 106 2671
Münz, Markus Munich, DE 9 115
Pompe, Cornelius Munich, DE 16 133
Rattel, Benno Munich, DE 24 219
Raum, Tobias Munich, DE 92 1685
Wolf, Andreas Munich, DE 116 1158

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