Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents

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United States of America Patent

PATENT NO 10301608
APP PUB NO 20170218348A1
SERIAL NO

15320490

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Abstract

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Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.

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Patent Owner(s)

Patent OwnerAddress
THE TEXAS A&M UNIVERSITY SYSTEM3369 TAMU COLLEGE STATION TX 77843

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bigley, Andrew N North Zulch, US 2 1
Raushel, Frank M College Station, US 3 1

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