Mannose-6-phosphate bearing peptides fused to lysosomal enzymes

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United States of America Patent

PATENT NO 10722559
APP PUB NO 20170232076A1
SERIAL NO

15503223

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Abstract

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A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSAK-SHI OSAKA 541-0045 541-0045

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Concino, Michael F Lexington, US 28 484
Iskenderian, Andrea Lexington, US 11 91
Low, Lieh Yoon Lexington, US 4 6
Lundberg, Dianna Lexington, US 9 78
Meiyappan, Muthuraman Lexington, US 22 103
Naimy, Hicham Lexington, US 3 6
Norton, Angela W Lexington, US 9 24
Romashko, Alla Lexington, US 8 85
Strack-Logue, Bettina Lexington, US 23 229
Zhang, Bohong Lexington, US 17 172

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