Tetrahydroisoquinoline derivatives

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United States of America Patent

PATENT NO 9914741
SERIAL NO

15429738

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

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Patent Owner(s)

  • ASTELLAS PHARMA INC.;CYTOKINECTICS, INCORPORATED

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ashcraft, Luke San Francisco, US 11 22
Collibee, Scott Emile San Carlos, US 5 3
Garard, Marc San Leandro, US 5 3
Kamikubo, Takashi Tokyo, JP 40 348
Kiyohara, Hiroshi Tokyo, JP 6 11
Lu, Pu-Ping Foster City, US 71 1263
Malik, Fady Burlingame, US 56 535
Matsushima, Yuji Tokyo, JP 10 24
Mihara, Kayoko Tokyo, JP 6 11
Miura, Masanori Tokyo, JP 44 187
Morgan, Bradley Paul Moraga, US 39 714
Ohe, Munemichi Tokyo, JP 6 3
Saito, Tomoyuki Tokyo, JP 46 315
Sato, Ippei Tokyo, JP 19 83
Shiina, Yasuhiro Tokyo, JP 9 5
Tanaka, Hiroaki Tokyo, JP 501 5229
Warrington, Jeffrey Michael San Mateo, US 5 3
Yamaki, Susumu Tokyo, JP 16 73

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