Method for quantitative characterization of substances with regard to their properties of binding to amyloid-β (Aβ) conformers

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United States of America Patent

PATENT NO 10746747
APP PUB NO 20170234890A1
SERIAL NO

14902760

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Abstract

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A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-β (Aβ) conformers, comprising the steps of: —fractionating a sample including various Aβ conformers; —immobilizing a biotinylated Aβ conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and —deriving the binding behavior of an aggregate quality control probe to the desired Aβ conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.

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Patent Owner(s)

Patent OwnerAddress
FORSCHUNGSZENTRUM JUELICH GMBHFACHBEREICH PATENTE JUELICH 52425

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brener, Oleksandr Duesseldorf, DE 3 1
Frenzel, Daniel Aachen, DE 3 3
Glueck, Julian Meerbusch, DE 1 0
Nagel-Steger, Luitgard Langenfeld, DE 10 17
Willbold, Dieter Juelich, DE 33 50

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